1 Department of Electrical Engineering, Technical University of Denmark2 Biomedical Engineering, Department of Electrical Engineering, Technical University of Denmark3 Technical University of Denmark4 Copenhagen University Hospital5 Copenhagen Center for Health Technology, Center, Technical University of Denmark
Idiopathic rapid eye-movement (REM) sleep behavior disorder (iRBD) has been found to be a strong early predictor for later development into Parkinson's disease (PD). iRBD is diagnosed by polysomnography but the manual evaluation is laborious, why the aims of this study are to develop supportive methods for detecting iRBD from electroencephalo-graphic (EEG) signals recorded during REM sleep. This method classified subjects from their EEG similarity with the two classes iRBD patients and control subjects. The feature sets used for classifying subjects were based on the relative powers of the EEG signals in different frequency bands. The classification was based on the fast and classical K-means and Bayesian classifiers. With a subject-specific re-scaling of the feature set and the use of a Bayesian classifier the performance reached 90% in both sensitivity and specificity. For the purpose of reducing the feature count, the features were evaluated with the statistical Smith-Satterthwaite test and by using sequential forward selection a well-performing feature subset was found which contained only five features, while attaining a sensitivity and a specificity of both 80%.
2013 35th Annual International Conference of the Ieee Engineering in Medicine and Biology Society (embc), 2013, Vol 2013, p. 5793-5796
biomechanics; diseases; electroencephalography; eye; feature extraction; medical disorders; medical signal processing; sensitivity; signal classification; sleep; statistical analysis; Engineered Materials, Dielectrics and Plasmas
Main Research Area:
2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2013