1 Helin Group, BRIC Research Groups, BRIC, Københavns Universitet2 Administration, BRIC Administration, BRIC, Københavns Universitet3 The Danish Stem Cell Center, Faculty of Health and Medical Sciences, Københavns Universitet4 Centre de Regulacio Genomica (CRG), Universitat Pompeu Fabra5 BRIC Administration, BRIC, Faculty of Health and Medical Sciences, Københavns Universitet6 BRIC Administration, BRIC, Faculty of Health and Medical Sciences, Københavns Universitet
Polycomb group (PcG) proteins are epigenetic regulators of transcription that have key roles in stem-cell identity, differentiation and disease. Mechanistically, they function within multiprotein complexes, called Polycomb repressive complexes (PRCs), which modify histones (and other proteins) and silence target genes. The dynamics of PRC1 and PRC2 components has been the focus of recent research. Here we discuss our current knowledge of the PRC complexes, how they are targeted to chromatin and how the high diversity of the PcG proteins allows these complexes to influence cell identity.
Journal review article
Nature Structural and Molecular Biology, 2013, Vol 20, Issue 10, p. 1147-55