Lønbro, Simon7; Dalgas, Ulrik8; Primdahl, Hanne9; Johansen, Jørgen4; Nielsen, Jakob Lindberg5; Aagaard, Per5; Hermann, Anne Pernille6; Overgaard, Jens7; Overgaard, Kristian8
1 Department of Clinical Medicine - Department of Experimental Clinical Oncology, Department of Clinical Medicine, Health, Aarhus University2 Department of Public Health - Sport Science, Department of Public Health, Health, Aarhus University3 Department of Clinical Medicine - The Department of Oncology, Department of Clinical Medicine, Health, Aarhus University4 Department of Oncology, Odense University Hospital, Odense5 Institute of Sports Science and Clinical Biomechanics, SDU Muscle Research Cluster (SMRC) , University of Southern Denmark6 Dept. of Endocrinology, Odense University Hospital7 Department of Clinical Medicine - Department of Experimental Clinical Oncology, Department of Clinical Medicine, Health, Aarhus University8 Department of Public Health - Sport Science, Department of Public Health, Health, Aarhus University9 Department of Clinical Medicine - The Department of Oncology, Department of Clinical Medicine, Health, Aarhus University
PURPOSE: The critical weight loss observed in head and neck squamous cell carcinoma (HNSCC) patients following radiotherapy is mainly due to loss of lean body mass. This is associated with decreases in muscle strength, functional performance and Quality of Life (QoL). The present study investigated the effect of progressive resistance training (PRT) on lean body mass, muscle strength and functional performance in HNSCC patients following radiotherapy. PATIENTS AND METHODS: Following radiotherapy HNSCC patients were randomized into two groups: Early Exercise (EE, n=20) initiated 12weeks of PRT followed by 12weeks of self-chosen physical activity. Delayed Exercise (DE, n=21) initiated 12weeks of self-chosen physical activity followed by 12weeks of PRT. Lean body mass, muscle strength, functional performance and QoL were evaluated at baseline and after week 12 and 24. RESULTS: In the first 12weeks lean body mass increased by 4.3% in EE after PRT and in the last 12weeks by 4.2% in DE after PRT. These increases were significantly larger than the changes after self-chosen physical activity (p⩽0.005). Regardless of PRT start-up time, the odds ratio of increasing lean body mass by more than 4% after PRT was 6.26 (p<0.05). PRT significantly increased muscle strength, whereas functional performance increased significantly more than after self-chosen physical activity only after delayed onset of PRT. Overall QoL improved significantly more in EE than DE from baseline to week 12. CONCLUSION: PRT effectively increased lean body mass and muscle strength in HNSCC patients following radiotherapy, irrespectively of early or delayed start-up.
Radiotherapy and Oncology, 2013, Vol 108, Issue 2, p. 314-319
Exercise; Head and neck cancer; Muscle function; Muscle mass