1 Gastrounit, Amager and Hvidovre Hospital, The Capital Region of Denmark2 Gastroenterology, Herlev and Gentofte Hospital, The Capital Region of Denmark3 Gastrounit, Medical Division, Gastrounit, Amager and Hvidovre Hospital, The Capital Region of Denmark
Acute phosphate nephropathy is a rare, but serious adverse event associated with the use of sodium phosphate for bowel cleansing. It may lead to permanent renal impairment and a need for dialysis. The aetiology is hyperphosphataemia caused by intestinal absorption of the cleanser. Risk factors include: advanced age, existing kidney disease, decreased intravascular volume, and medications affecting renal perfusion or function such as diuretics, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, and possibly nonsteroidal anti-inflammatory drugs.
Ugeskrift for Laeger, 2010, Vol 172, Issue 42, p. 2891-4