Wikkelsø, Anne Juul1; Afshari, Arash4; Stensballe, Jakob2; Johansson, Per Ingemar3
1 Anaesthesiology, Herlev, Herlev and Gentofte Hospital, The Capital Region of Denmark2 Anæstesi- og operationsklinikken HOC, HovedOrtoCentret Rigshospitalet, Rigshospitalet, The Capital Region of Denmark3 Klinisk Immunologisk Afdeling. Blodbanken og Vævstypelaboratoriet, Diagnostisk Center, Rigshospitalet, The Capital Region of Denmark4 Anaesthesiology, Department of - Juliane Marie Centre, Juliane Marie Centre, Rigshospitalet, The Capital Region of Denmark
Trauma-associated coagulopathies are at times present upon arrival at the emergency department. Hyperfibrinolysis is a condition in which the natural ability to dissolve blood clots is pathologically enhanced. It is present in 2-8% of trauma patients and associated with shock and increased mortality. Hyperfibrinolysis is easily detected by thromboelastography. The condition is treated with antifibrinolytics such as tranexamic acid--whereas transfusion with blood products is inefficient. This article explores the mechanisms and diagnostics of hyperfibrinolysis in trauma patients and the relevant treatment options.
Ugeskrift for Laeger, 2011, Vol 173, Issue 18, p. 1284-7