n the work reported here, a substrates adoption methodology for a series of similar substrates has been developed as part of a retrofit strategy. The objective is to achieve “fast, flexible and future” pharmaceutical production processes by adapting a generic modular process-plant template. Application of the methodology is illustrated through a case study from the pharmaceutical industry. Use of computer-aided models, methods and tools as part of the methodology is also highlighted.
Computer-aided Chemical Engineering, 2011, p. 291-295