Boiroux, Dimitri5; Finan, Daniel Aaron2; Poulsen, Niels Kjølstad5; Madsen, Henrik5; Jørgensen, John Bagterp6
1 Scientific Computing, Department of Informatics and Mathematical Modeling, Technical University of Denmark2 Department of Informatics and Mathematical Modeling, Technical University of Denmark3 Mathematical Statistics, Department of Informatics and Mathematical Modeling, Technical University of Denmark4 Center for Energy Resources Engineering, Center, Technical University of Denmark5 Department of Applied Mathematics and Computer Science, Technical University of Denmark6 Copenhagen Center for Health Technology, Center, Technical University of Denmark
In this paper, we apply model predictive control (MPC) for control of blood glucose in people with type 1 diabetes. The two first control strategies are based on nonlinear model predictive control (NMPC). The first control strategy is based on meal announcement in advance, while the second one considers meal announcement at mealtimes only. They give a quantitative upper bound on the achievable control performance. The third control strategy is a feedforward-feedback control strategy. This strategy uses a time-varying setpoint to reduce the risk of hypoglycemia. The feedback controller computes the optimal basal insulin infusion rate. The feedforward controller consists of a bolus calculator. It computes the optimal bolus, along with the time-varying glucose setpoint. We test these three strategies on a virtual patient with type 1 diabetes. The numerical results demonstrate the robustness of the last control strategy with respect to changes in the model parameters and incorrect meal announcement.
Computer-aided Chemical Engineering, 2011
Type 1 diabetes; Feedforward-feedback control; Nonlinear model predictive control
Main Research Area:
Computer - Aided Chemical Engineering
21st European Symposium on Computer Aided Process Engineering, 2011