1 Gastroenterology, Herlev and Gentofte Hospital, The Capital Region of Denmark2 unknown3 Department of Gastroinstestinal Surgery, Nordsjællands Hospital, The Capital Region of Denmark4 University of Copenhagen
Crohn's disease (CD) and ulcerative colitis (UC) are common forms of inflammatory bowel disease (IBD). Monozygotic (MZ) twin discordance rates and epidemiologic data implicate that environmental changes and epigenetic factors may play a pathogenic role in IBD. DNA methylation (the methylation of cytosines within CpG dinucleotides) is an epigenetic modification, which can respond to environmental influences. We investigated whether DNA methylation might be connected with IBD in peripheral blood leukocyte (PBL) DNA by utilizing genome-wide microarrays.
Inflammatory Bowel Diseases, 2012, Vol 18, Issue 12, p. 2334-41