1 The Hevesy Laboratory, Center for Nuclear Technologies, Technical University of Denmark2 Center for Nuclear Technologies, Technical University of Denmark3 Guy's Hospital4 University of Copenhagen5 Næstved Hospital6 Department of Electrical Engineering, Technical University of Denmark7 Guy's Hospital
Peptide receptor radionuclide therapy (PRRT) is a relatively new mode of internally targeted radiotherapy currently in clinical trials. In PRRT, ionizing radioisotopes conjugated to somatostatin analogues are targeted to neuroendocrine tumors (NETs) via somatostatin receptors. Despite promising clinical results, very little is known about the mechanism of tumor control. By using NCI-H727 cells in an in vivo murine xenograft model of human NETs, we showed that 177Lu-DOTATATE PRRT led to increased infiltration of CD86+ antigen presenting cells into tumor tissue. We also found that following treatment with PRRT, there was significantly increased tumor infiltration by CD49b+/FasL+ NK cells potentially capable of tumor killing. Further investigation into the immunomodulatory effects of PRRT will be essential in improving treatment efficacy.
Diagnostics, 2013, Vol 3, Issue 4, p. 344-55
177Lu-DOTATATE; CD49b+; CD86+; FasL+; NK Cells; PRRT; Dendritic Cells