Automatic semi-quantification of [(123)I]FP-CIT SPECT scans in healthy volunteers using BasGan version 2
- Authors:
-
- Nobili, Flavio ;
- Naseri, Mehrdad ;
- De Carli, Fabrizio ;
- Asenbaum, Susan ;
- Booij, Jan ;
- Darcourt, Jacques ;
- Ell, Peter ;
- Kapucu, Ozlem ;
- Kemp, Paul ;
- Svarer, Claus ;
- Morbelli, Silvia ;
- Pagani, Marco ;
- Sabri, Osama ;
- Tatsch, Klaus ;
- Tossici-Bolt, Livia ;
- Sera, Terez ;
- Borght, Tierry Vander ;
- Van Laere, Koen ;
- Varrone, Andrea
- Subtitle:
- results from the ENC-DAT database
- DOI:
- 10.1007/s00259-012-2304-8
- Abstract:
- PURPOSE: The aim of this study was to assess striatal dopamine transporter (DAT) availability in a large group of normal subjects. METHODS: The study included 122 healthy subjects, aged 18-83 years, recruited in the multicentre 'ENC-DAT' study (promoted by the European Association of Nuclear Medicine). Brain single photon emission computed tomography (SPECT) was acquired by means of dual-head cameras 3 h after [(123)I]FP-CIT administration. Specific to nondisplaceable binding ratios (SBRs) in the basal ganglia were computed using the 'BasGan' software, allowing automatic value extraction with partial volume effect correction. Multicentre camera inhomogeneity was taken into account by calibrating values on basal ganglia phantom data. SBR in each caudate nucleus (C) and putamen (P) were the dependent variables in a repeated measures general linear model analysis; age, gender, handedness and body mass index (BMI) were the independent variables. RESULTS: SBR values in C and P were significantly associated with age (mean rate decrease with age: 0.0306 per year, or 0.57 % of the general mean; p
- Type:
- Journal article
- Language:
- English
- Published in:
- European Journal of Nuclear Medicine and Molecular Imaging, 2013, Vol 40, Issue 4, p. 564-73
- Keywords:
- Journal Article; Multicenter Study
- Main Research Area:
- Medical science
- Publication Status:
- Published
- Review type:
- Peer Review
- Submission year:
- 2013
- Scientific Level:
- Scientific
- ID:
- 247526890
