1 Biomolecular Sciences, Department of Biology, Faculty of Science, Københavns Universitet2 University of Delaware3 Biomolecular Sciences, Department of Biology, Faculty of Science, Københavns Universitet4 University of Delaware
Disulfide bond formation is a key posttranslational modification, with implications for structure, function and stability of numerous proteins. While disulfide bond formation is a necessary and essential process for many proteins, it is deleterious and disruptive for others. Cells go to great lengths to regulate thiol-disulfide bond homeostasis, typically with several, apparently redundant, systems working in parallel. Dissecting the extent of oxidation and reduction of disulfides is an ongoing challenge due, in part, to the facility of thiol/disulfide exchange reactions.
Journal review article
Biochimica Et Biophysica Acta, 2014, Vol 1840, Issue 2, p. 838-846