Ballegaard, Vibe Cecilie Diederich4; Permin, H1; Katzenstein, T L2; Marquart, H V3; Schejbel, L3
1 Lungemedicinsk Afdeling L, Bispebjerg and Frederiksberg Hospital, The Capital Region of Denmark2 Infektionsmedicinsk Klinik, Finsencentret, Rigshospitalet, The Capital Region of Denmark3 Klinisk Immunologisk Afdeling. Blodbanken og Vævstypelaboratoriet, Diagnostisk Center, Rigshospitalet, The Capital Region of Denmark4 Institut for Klinisk Medicin
Common variable immunodeficiency (CVID) comprises a heterogeneous group of primary immunodeficiency disorders. Immunophenotyping of memory B cells at the time of diagnosis is increasingly used for the classification of patients into subgroups with different clinical prognoses. The EUROclass classification is a widely used method. Levels of somatic hypermutation (SHM) have proven useful as a prognostic marker for recurrent respiratory tract infections. As time of presentation and diagnosis is highly variable in CVID patients, and diagnostic delay is a common problem, it is important to know whether classification parameters are stable over time. The purpose of the study was to address this question in a cohort of 33 CVID patients followed from 3 to 19 years after diagnosis (average follow-up 8.8 years).
Journal of Clinical Immunology, 2013, Vol 33, Issue 6, p. 1067-77
Adolescent; Adult; Antibody Affinity; B-Lymphocyte Subsets; B-Lymphocytes; Cell Differentiation; Cell Proliferation; Child; Child, Preschool; Common Variable Immunodeficiency; Female; Follow-Up Studies; Humans; Immunologic Memory; Male; Time Factors; Young Adult