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Structural and dynamical aspects of skin studied by multiphoton excitation fluorescence microscopy-based methods

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Authors:
  • Bloksgaard, Maria ;
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    Orcid logo0000-0002-4474-9553
    Kardiovaskulær og Renal Forskning, Department of Molecular Medicine, Faculty of Health Sciences, SDU
  • Brewer, Jonathan R. ;
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    Department of Biochemistry and Molecular Biology, Faculty of Science, SDU
  • Bagatolli, Luis
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    Department of Biochemistry and Molecular Biology, Faculty of Science, SDU
DOI:
10.1016/j.ejps.2013.04.010
Abstract:
This mini-review reports on applications of particular multiphoton excitation microscopy-based methodologies employed in our laboratory to study skin. These approaches allow in-depth optical sectioning of the tissue, providing spatially resolved information on specific fluorescence probes' parameters. Specifically, by applying these methods, spatially resolved maps of water dipolar relaxation (generalized polarization function using the 6-lauroyl-2-(N,N-dimethylamino)naphthale probe), activity of protons (fluorescence lifetime imaging using a proton sensitive fluorescence probe--2,7-bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein) and diffusion coefficients of distinct fluorescence probes (raster imaging correlation spectroscopy) can be obtained from different regions of the tissue. Comparative studies of different tissue strata, but also between equivalent regions of normal and abnormal excised skin, including applications of fluctuation correlation spectroscopy on transdermal penetration of liposomes are presented and discussed. The data from the different studies reported reveal the intrinsic heterogeneity of skin and also prove these strategies to be powerful noninvasive tools to explore structural and dynamical aspects of the tissue.
Type:
Journal article
Language:
English
Published in:
European Journal of Pharmaceutical Sciences, 2013, Vol 50, Issue 5, p. 586-594
Main Research Area:
Science/technology
Publication Status:
Published
Review type:
Peer Review
Submission year:
2013
Scientific Level:
Scientific
ID:
247164836

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