DNA and RNA oxidations have been linked to diseases such as cancer, arteriosclerosis, neurodegeneration and diabetes. The prototype base modification studied is the 8-hydroxylation of guanine. DNA integrity is maintained by elaborate repair systems and RNA integrity is less studied but relies mainly on degradation.
Biochimica Et Biophysica Acta, 2014, Vol 1840, Issue 2, p. 801-808
Journal Article; Research Support, Non-U.S. Gov't; Review