A larger pituitary size is thought to reflect a greater activation of the hypothalamic-pituitary-adrenal (HPA) axis, which may be related to an increase in the number and size of corticotroph cells. Some studies, but not all, indicate that pituitary volume increases before or at the onset of psychosis. There is a need for at critical appraisal of the literature on this topic accompanied by a meta-analytical evaluation of the data.
Journal review article
Psychoneuroendocrinology, 2013, Vol 38, Issue 11, p. 2394-2404
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review