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Trends in the lifetime risk of COPD exacerbation requiring hospitalisation

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Authors:
  • Lykkegaard, Jesper ;
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    Research Unit of General Practice, Department of Public Health, Faculty of Health Sciences, SDU
  • Christensen, René Depont ;
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    Research Unit of General Practice, Department of Public Health, Faculty of Health Sciences, SDU
  • Davidsen, Jesper Rømhild ;
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    Orcid logo0000-0003-4128-4014
    Research Unit of General Practice, Department of Public Health, Faculty of Health Sciences, SDU
  • Støvring, Henrik ;
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    Research Unit of General Practice, Department of Public Health, Faculty of Health Sciences, SDU
  • Andersen, Morten ;
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    Research Unit of General Practice, Department of Public Health, Faculty of Health Sciences, SDU
  • Søndergaard, Jens
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    Research Unit of General Practice, Department of Public Health, Faculty of Health Sciences, SDU
DOI:
10.1183/09031936.00129312
Abstract:
This study aimed to estimate time-trends in the lifetime risk of hospitalisation with exacerbation of chronic obstructive pulmonary disease (COPD) in Denmark.During the period from 1994 to 2008 a register-based cohort study was conducted covering each subject in the entire population of Denmark (5.43 million in 2008).Based on previously validated diagnosis codes, all COPD hospitalisations were identified. Individual look-back periods of 8 years were used to determine first-time hospitalisations. From year 2002 to 2008 all first-time COPD hospitalised subjects aged 30 years and above were identified. The calculation of lifetime risk was based on age- and sex-specific first-time COPD hospitalisation rates and rates of COPD hospitalisation-free survival, assuming them to be calendar time stationary.The study included 23.9 million person-years of risk time and identified 48 959 first-time COPD hospitalisations. For 30-year-olds in Denmark, the lifetime risk of COPD hospitalisation was 12.0% (95% CI 11.9-12.2) for females and 10.9% (95% CI 10.8-11.1) for males. Trends were generally equal in both sexes. During the period from year 2002 to 2008, the rate of first-time COPD hospitalisations decreased, while the survival of never COPD hospitalised subjects increased. In consequence the lifetime risk of COPD hospitalisation remained constant.
Type:
Journal article
Language:
English
Published in:
European Respiratory Journal, 2013, Vol 42, Issue 4, p. 964-971
Main Research Area:
Medical science
Publication Status:
Published
Review type:
Peer Review
Submission year:
2013
Scientific Level:
Scientific
ID:
246492000

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