1 Salcini Group, BRIC Research Groups, BRIC, Københavns Universitet2 Salcini Group, BRIC, Faculty of Health and Medical Sciences, Københavns Universitet3 Salcini Group, BRIC Research Groups, BRIC, Københavns Universitet4 Salcini Group, BRIC, Faculty of Health and Medical Sciences, Københavns Universitet
We recently analyzed the functional roles of UTX-1 during development. utx-1 is an essential gene required for the correct embryonic and post-embryonic development of C. elegans, and it displays an H3K27me3 demethylase activity. Rescue experiments demonstrated that the enzymatic activity of UTX-1 is not relevant for its role in development. The phenotypes associated with loss of UTX-1 might, instead, be a result of compromised functions of an UTX-1-containing complex. Here we discuss the possible mechanisms by which UTX-1 contributes to normal development.