{"controller"=>"catalog", "action"=>"show", "id"=>"245458534"}
  • EN
  • DA

Danish NationalResearch Database

  • Search Publications & Researchers
  • Open Access Indicator
  • Publications
  • Researchers
Example Finds records
water{} containing the word "water".
water supplies"{}" containing the phrase "water supplies".
author:"Doe, John"author:"{}" containing the prase "Doe, John" in the author field.
title:IEEEtitle:{} containing the word "IEEE" in the title field.
Need more help? Advanced search tutorial
  • Selected (0)
  • History

A two-year follow-up study of salivary cortisol concentration and the risk of depression

    • Save to Mendeley
    • Export to BibTeX
    • Export to RIS
    • Email citation
Authors:
  • Grynderup, Matias Brødsgaard ;
    Close
    Department of Clinical Medicine - Occupational Medicine, Department of Clinical Medicine, Health, Aarhus University
  • Kolstad, Henrik A. ;
    Close
    Department of Clinical Medicine - Occupational Medicine, Department of Clinical Medicine, Health, Aarhus University
  • Mikkelsen, Sigurd ;
    Close
    unknown
  • Andersen, Johan Hviid ;
    Close
    Orcid logo0000-0003-1638-8276
    Department of Clinical Medicine - Arbejdsmedicinsk klinik, Herning, Department of Clinical Medicine, Health, Aarhus University
  • Bonde, Jens Peter ;
    Close
    unknown
  • Buttenschøn, Henriette Nørmølle ;
    Close
    Orcid logo0000-0003-3800-9169
    Department of Clinical Medicine - Translational Neuropsychiatry Unit, Department of Clinical Medicine, Health, Aarhus University
  • Kærgaard, Anette ;
    Close
    Department of Clinical Medicine - Arbejdsmedicinsk klinik, Herning, Department of Clinical Medicine, Health, Aarhus University
  • Kærlev, Linda ;
    Close
    unknown
  • Rugulies, Reiner ;
    Close
    unknown
  • Thomsen, Jane Frølund ;
    Close
    unknown
  • Vammen, Marianne Agergaard ;
    Close
    unknown
  • Mors, Ole ;
    Close
    Department of Clinical Medicine - The Department of General Psychiatry, Department of Clinical Medicine, Health, Aarhus University
  • Hansen, Ase Marie
    Close
    unknown
DOI:
10.1016/j.psyneuen.2013.03.013
Abstract:
Stress is a suspected cause of depression. High cortisol concentration, a biomarker of an activated stress response, has been found in depressed patients. The aim of this study was to determine if a high level of salivary cortisol is a risk factor of depression. In 2007, we enrolled 4467 public employees. Morning and evening salivary cortisol concentration were measured for each participant. Participants reporting high levels of depressive, burnout, or stress symptoms, assessed by questionnaires were assigned to a psychiatric interview. In this interview 98 participants were diagnosed with depression and subsequently excluded. Two years later in 2009, 2920 participants who had provided at least one valid saliva cortisol measurement at baseline participated at follow up. The psychiatric interviews were repeated and 62 cases of newly onset depression were diagnosed. Odds ratios of depression were estimated for every 1.0nmol/l increase in morning, evening, and daily mean cortisol concentration, as well as for the difference between morning and evening cortisol concentration. The risk of depression decreased by increasing daily mean cortisol concentration and by increasing difference between morning and evening concentrations, while morning and evening cortisol concentrations were not significantly associated with depression. The adjusted odds ratios for 1.0nmol/l increase in morning, evening, and daily mean cortisol concentration were 0.69 (95% CI: 0.45, 1.05), 0.87 (95% CI: 0.59, 1.28), and 0.53 (95% CI: 0.32, 0.90), respectively. The adjusted odds ratio for 1.0nmol/l increase in difference between morning and evening concentration were 0.64 (95% CI: 0.45, 0.90). This study did not support the hypothesis that high salivary cortisol concentration is a risk factor of depression, but indicate that low mean salivary cortisol concentration and a small difference between morning and evening cortisol concentration may be risk factors of depression.
Type:
Journal article
Language:
English
Published in:
Psychoneuroendocrinology, 2013, Vol 38, Issue 10, p. 2042-2050
Keywords:
Adult; Aged; Aged, 80 and over; Denmark; Depression; Female; Follow-Up Studies; Humans; Hydrocortisone; Male; Middle Aged; Risk Factors; Saliva; Young Adult; Journal Article; Research Support, Non-U.S. Gov't
Main Research Area:
Medical science
Publication Status:
Published
Review type:
Peer Review
Submission year:
2013
Scientific Level:
Scientific
ID:
245458534

Full text access

  • Doi Get publisher edition via DOI resolver
Checking for on-site access...

On-site access

At institutions

  • Aarhus university.en
  • Copenhagen university.en
  • University southern denmark
  • Capital region

Metrics

Feedback

Sitemap

  • Search
    • Statistics
    • Tutorial
    • Data
    • FAQ
    • Contact
  • Open Access
    • Overview
    • Development
    • FAQ
    • Contact
  • About
    • Institutions
    • Release History
    • Cookies and privacy policy

Copyright © 1998–2018.

Fivu en