1 Department of Clinical Medicine, The Faculty of Medicine, Aalborg University, VBN2 The Faculty of Medicine, Aalborg University, VBN3 Department of Endocrinology and Internal Medicine (MEA), Aarhus University Hospital, Aarhus, Denmark.4 unknown5 Institut for Klinisk Medicin - Medicinsk Endokrinologisk afdeling MEA, THG6 Institut for Klinisk Medicin - Klinisk Biokemisk Afdeling, NBG7 Klinik Medicin, The Faculty of Medicine, Aalborg University, VBN
BACKGROUND/OBJECTIVES: The objective of this study was to assess vitamin D status and possible consequences of low plasma 25-hydroxyvitamin D (25OHD) levels in a population of healthy mothers and their infants.Subjects/methods:A total of 107 women aged 24-41 years gave birth to 108 infants. They were followed up three times during 9 months. RESULTS: Cord blood 25OHD level (43.3 ± 20.4 nmol/l) on average was 62 ± 16% of maternal levels (73.3 ± 30.7 nmol/l), measured 1-2 weeks postpartum. Cord blood 25OHD correlated positively with maternal 25OHD levels (r=0.83, P<0.001). At birth, 23% of mothers and 61% of infants had 25OHD <50 nmol/l. Vitamin D deficiency (25OHD<25 nmol/l) was present in 66% of the children born by mothers with 25OHD levels below 50 nmol/l (P<0.01), whereas only one child was born with deficiency among mothers with 25OHD >50 nmol/l. During follow-up, most of the children (>85%) had 25OHD levels >50 nmol/l, which most likely was attributable to the use of supplements, as more than 95% of the children were given daily vitamin D supplements of 10 μg of vitamin D.Cord blood parathyroid hormone levels were very low (median 0.21; interquartile range 0.11-0.33 pmol/l), with increasing levels (P<0.01) reaching 3.08 (2.67-3.92 pmol/l) at the last visit. Vitamin D levels were not associated with anthropometric indices of the newborn infant or their growth during follow-up. CONCLUSIONS: Vitamin D deficiency is widespread in newborn. Maternal 25OHD levels above 50 nmol/l are needed to prevent vitamin D deficiency among newborn.
European Journal of Clinical Nutrition, 2013, Vol 67, Issue 10, p. 1022-1028