Tobacco smoking and aortic aneurysm: Two population-based studies

Birgitte F Sode; Børge G Nordestgaard; Morten Grønbæk; Morten Dahl

doi:10.1016/j.ijcard.2012.06.003

Tobacco smoking and aortic aneurysm

Authors:

Sode, Birgitte F ;
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unknown
Nordestgaard, Børge G ;
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Section of Diagnostic Sciences, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet
Grønbæk, Morten ;
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unknown
Dahl, Morten
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Graduate School of Health and Medical Sciences, Faculty of Health and Medical Sciences, Københavns Universitet

Subtitle:

Two population-based studies

DOI:

10.1016/j.ijcard.2012.06.003

Abstract:

BACKGROUND: We determined the predictive power of tobacco smoking on aortic aneurysm as opposed to other risk factors in the general population. METHODS: We recorded tobacco smoking and other risk factors at baseline, and assessed hospitalization and death from aortic aneurysm in 15,072 individuals from the Copenhagen City Heart Study followed for up to 34years and in 56,211 individuals from the Copenhagen General Population Study followed for up to 7years. RESULTS: During follow-up, 335 and 169 individuals developed aortic aneurysm outcomes in the Copenhagen City Heart Study and Copenhagen General Population Study, respectively. According to the magnitude of the hazard ratios, tobacco consumption was the most important risk factor for hospitalization and death from aortic aneurysm, followed by male sex and hypertension in both cohorts. The population attributable risk of aortic aneurysm outcomes due to tobacco consumption was 64% and 47% in the Copenhagen City Heart Study and Copenhagen General Population Study, respectively, and ranked highest among population attributable risks of aortic aneurysm in both cohorts. The absolute 10-year risk for hospitalization or death from aortic aneurysm in males and females consuming above 20g tobacco daily was 3.5% and 1.3%, among those >60years with plasma cholesterol >5mmol/L and a systolic blood pressure >140mmHg. CONCLUSIONS: Tobacco smoking is the most important predictor of future aortic aneurysm outcomes in the general population, with population attributable risks at or above 47%.

Type:

Journal article

Language:

English

Published in:

International Journal of Cardiology, 2012, Vol 167, Issue 5, p. 2271-77

Keywords:

Journal Article; Research Support, Non-U.S. Gov't

Main Research Area:

Medical science

Publication Status:

Published

Review type:

Peer Review

Submission year:

2012

Scientific Level:

Scientific

ID:

244833399

Tobacco smoking and aortic aneurysm

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