Willis, Tracey A2; Hollingsworth, Kieren G2; Coombs, Anna2; Sveen, Marie-Louise2; Andersen, Søren Peter2; Stojkovic, Tanya2; Eagle, Michelle2; Mayhew, Anna2; de Sousa, Paulo L2; Dewar, Liz2; Morrow, Jasper M2; Sinclair, Christopher D J2; Thornton, John S2; Bushby, Kate2; Lochmüller, Hanns2; Hanna, Michael G2; Hogrel, Jean-Yves2; Carlier, Pierre G2; Vissing, John3; Straub, Volker2
1 Department of Clinical Medicine, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet2 unknown3 Department of Clinical Medicine, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet
A Multicentre Longitudinal Study
Outcome measures for clinical trials in neuromuscular diseases are typically based on physical assessments which are dependent on patient effort, combine the effort of different muscle groups, and may not be sensitive to progression over short trial periods in slow-progressing diseases. We hypothesised that quantitative fat imaging by MRI (Dixon technique) could provide more discriminating quantitative, patient-independent measurements of the progress of muscle fat replacement within individual muscle groups.
P L O S One, 2013, Vol 8, Issue 8, p. 1-7
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't