With millions of humans infected yearly with HCV, leading to cirrhosis and cancer, a vaccine is urgently needed. Cultured virus particles constitute the antigen in most antiviral vaccines. A study in mice demonstrated induction of neutralizing antibodies by immunization with cell-culture-derived HCV, providing new possibilities for vaccine development.
Nature Reviews. Gastroenterology and Hepatology, 2013, Vol 10, Issue 9, p. 508-9