Hodgkin lymphoma (HL) survivors are at an increased risk of stroke because of carotid artery irradiation. However, for early-stage HL involved node radiation therapy (INRT) reduces the volume of normal tissue exposed to high doses. Here, we evaluate 3-dimensional conformal radiation therapy (3D-CRT), volumetric-modulated arc therapy (VMAT), and proton therapy (PT) delivered as INRT along with the extensive mantle field (MF) by comparing doses to the carotid arteries and corresponding risk estimates.
International Journal of Radiation: Oncology - Biology - Physics, 2013, Vol 87, Issue 2, p. 297-303
Adolescent; Adult; Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Carotid Arteries; Dose-Response Relationship, Radiation; Female; Hodgkin Disease; Humans; Male; Middle Aged; Organs at Risk; Proton Therapy; Radiotherapy Dosage; Radiotherapy, Conformal; Radiotherapy, Intensity-Modulated; Risk Assessment; Stroke; Survivors; Time Factors; Young Adult; Journal Article; Research Support, Non-U.S. Gov't