Barral, Sandra5; Cosentino, Stephanie5; Costa, Rosann5; Andersen, Stacey L5; Christensen, Kaare6; Eckfeldt, John H5; Newman, Anne B5; Perls, Thomas T5; Province, Michael A5; Hadley, Evan C5; Rossi, Winifred K5; Mayeux, Richard5
1 Epidemiology, Biostatistics and Biodemography, Department of Public Health, Det Sundhedsvidenskabelige Fakultet, SDU2 The Danish Twin Registry, Department of Public Health, Det Sundhedsvidenskabelige Fakultet, SDU3 Danish Aging Research Center, Department of Public Health, Det Sundhedsvidenskabelige Fakultet, SDU4 Human Genetics, Department of Clinical Research, Det Sundhedsvidenskabelige Fakultet, SDU5 unknown6 Epidemiology, Biostatistics and Biodemography, Department of Public Health, Det Sundhedsvidenskabelige Fakultet, SDU
Research to understand variability at the highest end of the cognitive performance distribution has been scarce. Our aim was to define a cognitive endophenotype based on exceptional episodic memory (EM) performance and to investigate familial aggregation of EM in families from the Long Life Family Study (LLFS). Using a sample of 1911 nondemented offspring of long-lived probands, we created a quantitative phenotype, EM (memory z ≥ 1.5), and classified LLFS families as EM and non-EM families based on the number of EM offspring. We then assessed differences in memory performance between LLFS relatives in the parental generation of EM families and those in non-EM families using multivariate analysis adjusted for APOE Apolipoprotein E genotype. LLFS relatives in the proband generation from EM families showed better EM performance than those from non-EM families (β = 0.74, standard error = 0.19, p = 1.4 × 10(-4)). We demonstrated that there is a familial correlation of the EM endophenotype, suggesting that genetic variants might influence memory performance in long-lived families.
Neurobiology of Aging, 2013, Vol 34, Issue 11, p. 2445-8
Exceptional memory; Genetic variants; Long Life Family Study; Quantitative trait