Barder, Helene Eidsmo2; Sundet, Kjetil2; Rund, Bjørn Rishovd3; Evensen, Julie2; Hegelstad, Wenche ten Velden4; Joa, Inge4; Johannessen, Jan Olav4; Langeveld, Hans4; Larsen, T.K.4; Melle, Ingrid2; Opjordsmoen, Stein2; Røssberg, Jan Ivar2; Simonsen, Erik1; Vaglum, Per3; McGlashan, Thomas5; Friis, Svein2
1 The Department of Psychology and Educational Studies, Roskilde University2 Oslo universitetssykehus3 Universitetet i Oslo4 Stavanger Universitetssjukehus5 Yale University
Associations between illness severity and cognitive course
Cognitive deficits are documented in first-episode psychosis (FEP), but the continuing course is not fully understood. The present study examines the longitudinal development of neurocognitive function in a five year follow-up of FEP-patients, focusing on the relation to illness severity, as measured by relapses and diagnostic subgroups. The study is an extension of previous findings from the TIPS-project, reporting stability over the first two years. Sixty-two FEP patients (53% male, age 28 ± 9 years) were neuropsychologically examined at baseline and at 1, 2, and 5 year follow-ups. The test battery was divided into five indices; Verbal Learning, Executive Function, Impulsivity, Motor Speed, andWorking Memory. To investigate the effect of illness severity, the sample was divided in groups based on number of relapses, and diagnostic subgroups, respectively. Impulsivity and Working Memory improved significantly in the first two years, followed by no change over the next three years.Motor Speed decreased significantly from2 to 5 years. Number of relapseswas significantly related to Verbal Learning and WorkingMemory, showing a small decrease and less improvement, respectively, in patients with two or more episodes. No significant association was found with diagnostic group. Neurocognitive stability as well as change was found in a sample of FEP-patients examined repeatedly over 5 years. Of potential greater importance for understanding howpsychotic illnesses progress, is the finding of significant associations between neurocognition and number of relapses but not diagnostic group, indicating that neurocognition is more related to recurring psychotic episodes than to the descriptive diagnosis per se.
Schizophrenia Research, 2013, Vol 149, Issue 1-3, p. 63-69