Hwabejire, John O2; Jin, Guang3; Imam, Ayesha M3; Duggan, Michael3; Sillesen, Martin4; Deperalta, Danielle3; Jepsen, Cecilie H3; Lu, Jennifer3; Li, Yongqing3; deMoya, Marc A3; Alam, Hasan B3
1 Anæstesi- og operationsklinikken HOC, HovedOrtoCentret Rigshospitalet, Rigshospitalet, The Capital Region of Denmark2 Division of Trauma, Emergency Surgery and Surgical Critical Care, Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA.3 unknown4 Department of Anaesthesiology, Amager and Hvidovre Hospital, The Capital Region of Denmark
Cerebral metabolic derangement and excitotoxicity play critical roles in the evolution of traumatic brain injury (TBI). We have shown previously that treatment with large doses of valproic acid (VPA) decreases the size of brain lesion. The goal of this experiment was to determine whether this effect was owing to metabolic modulation.