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Effector CD4 and CD8 T Cells and Their Role in the Tumor Microenvironment

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Authors:
  • Hadrup, Sine ;
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    Haematology, Department of, Herlev and Gentofte Hospital, The Capital Region of Denmark
  • Donia, Marco ;
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    Orcid logo0000-0003-4966-9752
    Center for Cancer Immune Therapy (CCIT), Haematology, Department of, Herlev and Gentofte Hospital, The Capital Region of Denmark
  • thor Straten, Per
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    Orcid logo0000-0002-4731-4969
    Haematology, Department of, Herlev and Gentofte Hospital, The Capital Region of Denmark
DOI:
10.1007/s12307-012-0127-6
Abstract:
T cells in tumors-the so-called tumor infiltrating lymphocytes (TIL) have been studied intensively over the past years. Compelling evidence point to a clinical relevance for high numbers of T cells at the tumor site with CD8 memory T cells as a key denominator for overall survival (OS) in patients with colo-rectal cancer (CRC), and also for others solid cancers. These data goes hand in hand with studies of clonality of TIL showing the T cells among TIL are expanded clonally, and also that tumor specific T cells of CD4 as well as CD8 type are enriched at the tumor site. The tumor microenvironment is hostile to T cell function e.g., due to expression of enzymes that depletes the amino acids tryptophan and arginine, high concentration of tumor secreted lactate, and presence innate cells or regulatory T cells both with suppressive activity. Analyses of the specificity of TILs in melanoma demonstrate that quite few known antigens are in fact recognized by these cultures underscoring patient unique and/or mutated antigens may represent important target for recognition.
Type:
Journal article
Language:
English
Published in:
Cancer Microenvironment, 2012
Keywords:
Journal Article
Main Research Area:
Medical science
Publication Status:
Published
Review type:
Peer Review
Submission year:
2012
Scientific Level:
Scientific
ID:
243668721

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