- Authors:
-
- Hadrup, Sine ;
-
Donia, Marco
;
Close
0000-0003-4966-9752
Center for Cancer Immune Therapy (CCIT), Haematology, Department of, Herlev and Gentofte Hospital, The Capital Region of Denmark -
thor Straten, Per
Close0000-0002-4731-4969
Haematology, Department of, Herlev and Gentofte Hospital, The Capital Region of Denmark
- DOI:
- 10.1007/s12307-012-0127-6
- Abstract:
- T cells in tumors-the so-called tumor infiltrating lymphocytes (TIL) have been studied intensively over the past years. Compelling evidence point to a clinical relevance for high numbers of T cells at the tumor site with CD8 memory T cells as a key denominator for overall survival (OS) in patients with colo-rectal cancer (CRC), and also for others solid cancers. These data goes hand in hand with studies of clonality of TIL showing the T cells among TIL are expanded clonally, and also that tumor specific T cells of CD4 as well as CD8 type are enriched at the tumor site. The tumor microenvironment is hostile to T cell function e.g., due to expression of enzymes that depletes the amino acids tryptophan and arginine, high concentration of tumor secreted lactate, and presence innate cells or regulatory T cells both with suppressive activity. Analyses of the specificity of TILs in melanoma demonstrate that quite few known antigens are in fact recognized by these cultures underscoring patient unique and/or mutated antigens may represent important target for recognition.
- Type:
- Journal article
- Language:
- English
- Published in:
- Cancer Microenvironment, 2012
- Keywords:
- Journal Article
- Main Research Area:
- Medical science
- Publication Status:
- Published
- Review type:
- Peer Review
- Submission year:
- 2012
- Scientific Level:
- Scientific
- ID:
- 243668721
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