van Middelkoop, Marienke3; Dziedzic, Krysia S3; Doherty, Michael3; Zhang, Weiya3; Bijlsma, Johannes W3; McAlindon, Timothy E3; Lohmander, Stefan5; Bierma-Zeinstra, Sita M A3
1 Department of Sports Science and Clinical Biomechanics, Det Sundhedsvidenskabelige Fakultet, SDU2 Musculoskeletal Function and Physiotherapy, Department of Sports Science and Clinical Biomechanics, Det Sundhedsvidenskabelige Fakultet, SDU3 unknown4 Orthopaedics, Department of Clinical Research, Det Sundhedsvidenskabelige Fakultet, SDU5 Orthopaedics, Department of Clinical Research, Det Sundhedsvidenskabelige Fakultet, SDU
an OA Trial Bank protocol for a systematic review
Based on small to moderate effect sizes for the wide range of symptomatic treatments in osteoarthritis (OA), and on the heterogeneity of OA patients, treatment guidelines for OA have stressed the need for research on clinical predictors of response to different treatments. A meta-analysis to quantify the effect modified by the predictors using individual patient data (IPD) is suggested. The initiative to collect and analyze IPD in OA research is commenced by the OA Trial Bank. The study aims are therefore: to evaluate the efficacy of intra-articular glucocorticoids for knee or hip OA in specific subgroups of patients with severe pain and (mild) inflammatory signs, over both short-term and long-term follow-up, using IPD from existing studies; to reach consensus on the rules for cooperation in a consortium; and to develop and explore the methodological issues of meta-analysis with individual OA patient data.