Graves' hyperthyroidism is an autoimmune disease causing hyperfunction of the thyroid gland. The concentration of selenium is high in the thyroid gland and two important groups of enzymes within the thyroid are selenoproteins, that is, they depend on selenium. Selenium may have beneficial effects on autoimmune hypothyroidism and on Graves' orbitopathy, but the effects of selenium on Graves' hyperthyroidism is unknown.We hypothesize that adjuvant selenium may be beneficial in the treatment of Graves' hyperthyroidism. The objective is to investigate if selenium supplementation plus standard treatment with anti-thyroid drugs versus standard treatment with anti-thyroid drugs will lead to a decrease in anti-thyroid drug treatment failure (that is, failure to remain euthyroid, without further treatment, one year after cessation of anti-thyroid drug treatment), faster and longer lasting remission (that is, anti-thyroid drug treatment success), and improved quality of life in patients with Graves' hyperthyroidism.
Trials, 2013, Vol 14, Issue April, p. 1-10
Antithyroid Agents; Clinical Protocols; Denmark; Dietary Supplements; Graves Disease; Humans; Patient Selection; Quality of Life; Research Design; Selenomethionine; Time Factors; Treatment Outcome; Yeast, Dried; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't