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Striatal Dopamine Transporter Binding Does Not Correlate with Clinical Severity in Dementia with Lewy Bodies

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Authors:
  • Ziebell, Morten ;
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    unknown
  • Andersen, Birgitte B ;
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    unknown
  • Pinborg, Lars H ;
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    Department of Clinical Medicine, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet
  • Knudsen, Gitte M ;
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    unknown
  • Stokholm, Jette ;
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    unknown
  • Thomsen, Gerda ;
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    unknown
  • Karlsborg, Merete ;
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    unknown
  • Høgh, Peter ;
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    Kirurgi og Intern Medicin
  • Mørk, Mette Louise ;
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    unknown
  • Hasselbalch, Steen G
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    Department of Clinical Medicine, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet
DOI:
10.2967/jnumed.112.114025
Abstract:
Patients who have dementia with Lewy bodies (DLB) show both clinical and histopathologic overlap with Alzheimer disease patients and Parkinson disease patients. In this study, we correlated the core features of DLB (dementia, parkinsonism, hallucinations, and fluctuations) with striatal dopamine transporter (DAT) availability as assessed with SPECT and (123)I-N-(3-iodoprop-2E-enyl)-2-β-carbomethoxy-3β-(4-methylphenyl) nortropane ((123)I-PE2I) in patients with newly diagnosed DLB. METHODS: Two hundred eighty-eight patients were consecutively included in the study as they were referred for diagnostic SPECT scanning of DAT with (123)I-PE2I. Of those patients, 51 had, on the basis of clinical guideline criteria, a probable-DLB diagnosis at follow-up 16 ± 11.6 mo later. Before or on the day of the SPECT scan, DLB patients had a routine neurologic examination including Hoehn and Yahr grading and were cognitively evaluated with the Mini Mental State Examination. RESULTS: There was no correlation between Mini Mental State Examination, Hoehn and Yahr score, fluctuations or hallucinations, and striatal DAT availability as measured with (123)I-PE2I and SPECT. CONCLUSION: In patients with newly diagnosed DLB, symptoms are not associated with a reduction in striatal DAT despite its firm involvement in DLB pathology.
Type:
Journal article
Language:
English
Published in:
Journal of Nuclear Medicine, 2013, Vol 54, Issue 7, p. 1072-6
Keywords:
Aged; Biological Markers; Brain; Corpus Striatum; Denmark; Dopamine Plasma Membrane Transport Proteins; Female; Humans; Lewy Body Disease; Male; Nortropanes; Prevalence; Protein Binding; Radiopharmaceuticals; Reproducibility of Results; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index; Statistics as Topic; Journal Article; Research Support, Non-U.S. Gov't
Main Research Area:
Medical science
Publication Status:
Published
Review type:
Peer Review
Submission year:
2013
Scientific Level:
Scientific
ID:
242972370

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