van Eupen, M G A2; Schram, M T2; Colhoun, H M2; Hanssen, N M J2; Niessen, H W M2; Tarnow, Lise3; Parving, H H1; Rossing, Pia4; Stehouwer, C D A2; Schalkwijk, C G2
1 Endocrinology, Department of, Abdominal Centre, Rigshospitalet, The Capital Region of Denmark2 unknown3 Institut for Klinisk Medicin - Klinisk Epidemiologi4 Finance Division
Methylglyoxal (MGO) is a major precursor for advanced glycation end-products (AGEs), which are thought to play a role in vascular complications in diabetes. Known MGO-arginine-derived AGEs are 5-hydro-5-methylimidazolone (MG-H1), argpyrimidine and tetrahydropyrimidine (THP). We studied THP in relation to type 1 diabetes, endothelial dysfunction, low-grade inflammation, vascular complications and atherosclerosis.