Rastogi, Anshul3; Kubassova, Olga3; Krasnosselskaia, Lada V3; Lim, Adrian K P3; Satchithananda, Keshthra3; Boesen, Mikael1; Binks, Michael3; Hajnal, Joseph V3; Taylor, Peter C3
1 Røntgenafdelingen Bispebjerg og Frederiksberg Hospital, Bispebjerg and Frederiksberg Hospital, The Capital Region of Denmark2 Parker Instituttet, Bispebjerg and Frederiksberg Hospital, The Capital Region of Denmark3 unknown
one-year longitudinal observational study
Dynamic contrast enhanced (DCE)-MRI has great potential to provide quantitative measure of inflammatory activity in rheumatoid arthritis. There is no current benchmark to establish the stability of signal in the joints of healthy subjects when imaged with DCE-MRI longitudinally, which is crucial so as to differentiate changes induced by treatment from the inherent variability of perfusion measures. The objective of this study was to test a pixel-by-pixel parametric map based approach for analysis of DCE-MRI (Dynamika) and to investigate the variability in signal characteristics over time in healthy controls using longitudinally acquired images.
European Journal of Radiology, 2013, Vol 82, Issue 8, p. 1286-91