Hartling, Hans Jakob3; Thørner, Lise W.3; Erikstrup, Christian7; Zinyama, Rutendo4; Kallestrup, Per8; Gomo, Exnevia5; Nielsen, Susanne D.3; Ullum, Henrik6
1 Department of Clinical Medicine - Department of Clinical Immunology, Department of Clinical Medicine, Health, Aarhus University2 Department of Public Health - Department of Health Services Research, Department of Public Health, Health, Aarhus University3 Viroimmunology Research Unit, Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital4 Medical Research Council of Zimbabwe, Ministry of Health and Child Welfare5 Department of Medical Laboratory Sciences, University of Zimbabwe, Zimbabwe6 Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen7 Department of Clinical Medicine - Department of Clinical Immunology, Department of Clinical Medicine, Health, Aarhus University8 Department of Public Health - Department of Health Services Research, Department of Public Health, Health, Aarhus University
OBJECTIVES:: Recently, polymorphisms in the gene encoding the Interleukin-7 receptor α (IL7RA) have been shown to influence the CD4 cell count in HIV-infected individuals. The objective of this study was to examine the impact of 10 single nucleotide polymorphisms (SNPs) in or in close proximity to the IL7RA on mortality among 152 untreated HIV-infected in a Zimbabwean cohort. METHODS:: Patients were followed prospectively, median time of follow-up 3.9 year. SNPs were genotyped using competitive allele-specific PCR. Cox regression was used for survival analyses. RESULTS:: We found an increased mortality among carriers of the IL7RA, rs6897932, T-allele (hazard ratio (HR): 2.56 (95% CI 1.22-5.35), P = 0.013). This association remained significant after adjusting for age, sex, baseline HIV-RNA and baseline CD4 cell count (HR = 2.36 (95% CI 1.06-2.58), P = 0.036). CONCLUSION:: The results suggest an association between the IL7RA, rs6897932, T-allele and increased mortality among untreated HIV-infected, Zimbabwean individuals.