Swenson, M Shel4; Anderson, Joshua4; Ash, Andrew4; Gaurav, Prashant5; Sükösd, Zsuzsanna8; Bader, David A5; Harvey, Stephen C6; Heitsch, Christine E7
1 Bioinformatics Research Centre (BiRC), Science and Technology, Aarhus University2 Department of Molecular Biology and Genetics, Science and Technology, Aarhus University3 Interdisciplinary Nanoscience Center, Science and Technology, Aarhus University4 School of Mathematics, Georgia Institute of Technology5 College of Computing, Georgia Institute of Technology6 School of Biology, Georgia Institute of Technology7 College of Computing, Georgia Institute of Technolog8 Bioinformatics Research Centre (BiRC), Science and Technology, Aarhus University
Accurate and efficient RNA secondary structure prediction remains an important open problem in computational molecular biology. Historically, advances in computing technology have enabled faster and more accurate RNA secondary structure predictions. Previous parallelized prediction programs achieved significant improvements in runtime, but their implementations were not portable from niche high-performance computers or easily accessible to most RNA researchers. With the increasing prevalence of multi-core desktop machines, a new parallel prediction program is needed to take full advantage of today's computing technology. Findings: We present here the first implementation of RNA secondary structure prediction by thermodynamic optimization for modern multi-core computers. We show that GTfold predicts secondary structure in less time than UNAfold and RNAfold, without sacrificing accuracy, on machines with four or more cores. Conclusions GTfold supports advances in RNA structural biology by reducing the timescales for secondary structure prediction. The difference will be particularly valuable to researchers working with lengthy RNA sequences, such as RNA viral genomes.