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The extension of a DNA double helix by an additional Watson-Crick base pair on the same backbone

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Authors:
  • Kumar, P. ;
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    NAC, Institut for Fysik og Kemi, Department of Physics, Chemistry and Pharmacy, Faculty of Science, SDU
  • Sharma, P. K. ;
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    Department of Physics, Chemistry and Pharmacy, Faculty of Science, SDU
  • Madsen, Charlotte S. ;
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    Neurology, Department of Clinical Research, Faculty of Health Sciences, SDU
  • Petersen, Michael ;
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    Orcid logo0000-0002-0997-7657
    Department of Physics, Chemistry and Pharmacy, Faculty of Science, SDU
  • Nielsen, P.
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    NAC, Institut for Fysik og Kemi, Department of Physics, Chemistry and Pharmacy, Faculty of Science, SDU
DOI:
10.1002/cbic.201300086
Abstract:
Additional base pair: The DNA duplex can be extended with an additional Watson-Crick base pair on the same backbone by the use of double-headed nucleotides. These also work as compressed dinucleotides and form two base pairs with cognate nucleobases on the opposite strand.
Type:
Journal article
Language:
English
Published in:
Chembiochem, 2013, Vol 14, Issue 9, p. 1072-1074
Keywords:
Base Pairing DNA/*chemistry/metabolism Molecular Dynamics Simulation Nucleic Acid Conformation Nucleotides/chemistry Thermodynamics
Main Research Area:
Science/technology
Publication Status:
Published
Review type:
Peer Review
Submission year:
2013
Scientific Level:
Scientific
ID:
242359291

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