The extension of a DNA double helix by an additional Watson-Crick base pair on the same backbone

P. Kumar; P. K. Sharma; Charlotte S. Madsen; Michael Petersen; P. Nielsen

doi:10.1002/cbic.201300086

The extension of a DNA double helix by an additional Watson-Crick base pair on the same backbone

Authors:

Kumar, P. ;
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NAC, Institut for Fysik og Kemi, Department of Physics, Chemistry and Pharmacy, Faculty of Science, SDU
Sharma, P. K. ;
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Department of Physics, Chemistry and Pharmacy, Faculty of Science, SDU
Madsen, Charlotte S. ;
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Neurology, Department of Clinical Research, Faculty of Health Sciences, SDU
Petersen, Michael ;
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0000-0002-0997-7657
Department of Physics, Chemistry and Pharmacy, Faculty of Science, SDU
Nielsen, P.
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NAC, Institut for Fysik og Kemi, Department of Physics, Chemistry and Pharmacy, Faculty of Science, SDU

DOI:

10.1002/cbic.201300086

Abstract:

Additional base pair: The DNA duplex can be extended with an additional Watson-Crick base pair on the same backbone by the use of double-headed nucleotides. These also work as compressed dinucleotides and form two base pairs with cognate nucleobases on the opposite strand.

Type:

Journal article

Language:

English

Published in:

Chembiochem, 2013, Vol 14, Issue 9, p. 1072-1074

Keywords:

Base Pairing DNA/*chemistry/metabolism Molecular Dynamics Simulation Nucleic Acid Conformation Nucleotides/chemistry Thermodynamics

Main Research Area:

Science/technology

Publication Status:

Published

Review type:

Peer Review

Submission year:

2013

Scientific Level:

Scientific

ID:

242359291

The extension of a DNA double helix by an additional Watson-Crick base pair on the same backbone

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