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Escherichia coli clonal group A causing bacteraemia of urinary tract origin

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Authors:
  • Skjøt-Rasmussen, L ;
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    unknown
  • Olsen, S S ;
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    unknown
  • Jakobsen, L ;
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    Clinical Microbiology, Department of, Amager and Hvidovre Hospital, The Capital Region of Denmark
  • Ejrnaes, K ;
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    Pathology, Department of, Herlev and Gentofte Hospital, The Capital Region of Denmark
  • Scheutz, Flemming ;
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    unknown
  • Lundgren, B ;
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    Clinical Microbiology, Department of, Amager and Hvidovre Hospital, The Capital Region of Denmark
  • Frimodt-Møller, N ;
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    Clinical Microbiology, Department of, Amager and Hvidovre Hospital, The Capital Region of Denmark
  • Hammerum, Anette Marie
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    Department of Microbiology
DOI:
10.1111/j.1469-0691.2012.03961.x
Abstract:
Clin Microbiol Infect ABSTRACT: Escherichia coli clonal group A (CgA) causes disease in humans. This is the first study investigating the prevalence of CgA among E. coli from non-urine, extraintestinal infections in a northern European country. E. coli blood (n = 196) and paired urine (n = 195) isolates from the same patients with bacteraemia of urinary tract origin were analysed. The isolates were collected from January 2003 through May 2005 at four hospitals in Copenhagen, Denmark. Pulsed-field gel electrophoresis (PFGE) patterns, antimicrobial resistance and patient characteristics were determined for all CgA isolates; presence of virulence-associated genes (VAGs) and serotypes were determined for the blood CgA isolates. Thirty blood isolates (15%) belonged to CgA. CgA blood isolates were associated with female patients and sulfamethoxazole-trimethoprim resistance and they harboured a distinctive VAG profile. The blood and urine isolates from each pair were found to be related in 26 of 27 CgA blood/urine pairs, confirming a urinary tract origin of infection. Furthermore, a relationship between the PFGE patterns of CgA blood/urine isolates and CgA isolates from UTI patients in general practice and a CgA isolate from a community-dwelling human reported previously, was found, suggesting a community origin of CgA. The finding of CgA strains in 15% of the E. coli bloodstream infections with a urinary tract origin in Denmark suggests that CgA constitutes an important clonal lineage among extraintestinal pathogenic E. coli. A reservoir of this pathogenic E. coli group in the community causing not only UTI but also more severe infections such as bacteraemia has implications for public health.
Type:
Journal article
Language:
English
Published in:
Clinical Microbiology and Infection, 2013, Vol 19, Issue 7, p. 656-61
Keywords:
Journal Article
Main Research Area:
Medical science
Publication Status:
Published
Review type:
Peer Review
Submission year:
2013
Scientific Level:
Scientific
ID:
242237129

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