Bossi, Rossana3; Vinggaard, Anne Marie4; Taxvig, Camilla1; Boberg, Julie1; Bonefeld-Jørgensen, Eva Cecilie3
1 National Food Institute, Technical University of Denmark2 Division of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark3 unknown4 Copenhagen Center for Health Technology, Center, Technical University of Denmark
Concentrations of pesticides and selected metabolites in rat urine and amniotic fluid were determined as biomarker upon oral administration of Wistar rats to two pesticide mixtures consisting of three to five pesticides (bitertanol, propiconazole, cypermethrin, malathion, and terbuthylazine). The pesticides and their metabolites were found in rat amniotic fluid and urine, generally in dose-response concentrations in relation to dosage. The measurement of the substances in the amniotic fluid indicated that the fetus was exposed to the pesticides as well as their metabolites. Moreover, the pesticides detected in urine demonstrated the exposure as well as the ability of the rat to excrete these compounds.
International Journal of Environmental Research and Public Health, 2013, Vol 10, Issue 6, p. 2271-2281
Pesticides; Gestational exposure; In vivo experiment; Wistar rats