1 Analytical Biosciences, Department of Pharmacy, Faculty of Health and Medical Sciences, Københavns Universitet2 School of Pharmacy, University of Oslo3 Analytical Biosciences, Department of Pharmacy, Faculty of Health and Medical Sciences, Københavns Universitet
micro-scale liquid-liquid-liquid extraction in the 96-well format
This paper reports development of a new approach towards analytical liquid-liquid-liquid membrane extraction termed parallel artificial liquid membrane extraction. A donor plate and acceptor plate create a sandwich, in which each sample (human plasma) and acceptor solution is separated by an artificial liquid membrane. Parallel artificial liquid membrane extraction is a modification of hollow-fiber liquid-phase microextraction, where the hollow fibers are replaced by flat membranes in a 96-well plate format.
Bioanalysis, 2013, Vol 5, Issue 11, p. 1377-85
Chromatography, Liquid; Equipment Design; Humans; Limit of Detection; Liquid Phase Microextraction; Membranes, Artificial; Pharmaceutical Preparations; Tandem Mass Spectrometry