Genome-wide Association and Longitudinal Analyses Reveal Genetic Loci Linking Pubertal Height Growth, Pubertal Timing, and Childhood Adiposity
- Authors:
-
- Cousminer, Diana L ;
- Berry, Diane J ;
- Timpson, Nicholas J ;
- Ang, Xiao Wei Emmiline ;
- Thiering, Elisabeth ;
- Byrne, Enda ;
- Taal, H Rob ;
- Huikari, Ville ;
- Bradfield, Jonathan P ;
- Kerkhof, Marjan ;
- Groen-Blokhuis, Maria M ;
- Kreiner-Møller, Eskil ;
- Marinelli, Marcella ;
- Holst, Claus ;
- Leinonen, Jaakko T ;
- Perry, John R B ;
- Surakka, Ida ;
- Pietiläinen, Olli ;
- Kettunen, Johannes ;
- Anttila, Verneri ;
- Kaakinen, Marika ;
- Sovio, Ulla ;
- Pouta, Anneli ;
- Das, Shikta ;
- Lagou, Vasiliki ;
- Power, Chris ;
- Prokopenko, Inga ;
- Evans, David M ;
- Kemp, John P ;
- St Pourcain, Beate ;
- Ring, Sue ;
- Palotie, Aarno ;
- Kajantie, Eero ;
- Osmond, Clive ;
- Lehtimäki, Terho ;
- Viikari, Jorma S ;
- Kähönen, Mika ;
- Warrington, Nicole M ;
- Lye, Stephen J ;
- Palmer, Lyle J ;
- Tiesler, Carla M T ;
- Flexeder, Claudia ;
- Montgomery, Grant W ;
- Medland, Sarah E ;
- Hofman, Albert ;
- Hakonarson, Hakon ;
- Guxens, Mònica ;
- Bartels, Meike ;
- Salomaa, Veikko ;
- Murabito, Joanne ;
- Kaprio, Jaakko ;
-
Sørensen, Thorkild I A
;
Close
0000-0003-4821-430X
Section for Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, Københavns Universitet - Ballester, Ferran ;
-
Bisgaard, Hans
;
Close0000-0003-4131-7592
Section of Gynaecology, Obstetrics and Paediatrics, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet - Boomsma, Dorret I ;
- Koppelman, Gerard H ;
- Grant, Struan F A ;
- Jaddoe, Vincent W V ;
- Martin, Nicholas G ;
- Heinrich, Joachim ;
- Pennell, Craig E ;
- Raitakari, Olli ;
- Eriksson, Johan G ;
- Smith, George Davey ;
- Hyppönen, Elina ;
- Järvelin, Marjo-Riitta ;
- McCarthy, Mark I ;
- Ripatti, Samuli ;
- Widén, Elisabeth
- DOI:
- 10.1093/hmg/ddt104
- Abstract:
- The pubertal height growth spurt is a distinctive feature of childhood growth reflecting both the central onset of puberty and local growth factors. While little is known about the underlying genetics, growth variability during puberty correlates with adult risks for hormone-dependent cancer and adverse cardiometabolic health. The only gene so far associated with pubertal height growth, LIN28B, pleiotropically influences childhood growth, puberty, and cancer progression, pointing to shared underlying mechanisms.To discover genetic loci influencing pubertal height and growth and place them in context of overall growth and maturation, we performed genome-wide association (GWA) meta-analyses in up to 18,737 European samples utilizing longitudinally collected height measurements. We found significant associations (P
- Type:
- Journal article
- Language:
- English
- Published in:
- Human Molecular Genetics, 2013, Vol 22, Issue 13, p. 2735-2747
- Keywords:
- Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
- Main Research Area:
- Medical science
- Publication Status:
- Published
- Review type:
- Peer Review
- Submission year:
- 2013
- Scientific Level:
- Scientific
- ID:
- 242225424
