Roager, Henrik Munch1; Licht, Tine Rask3; Kellebjerg Poulsen, Sanne4; Meinert Larsen, Thomas4; Bahl, Martin Iain1
1 National Food Institute, Technical University of Denmark2 Division of Food Microbiology, National Food Institute, Technical University of Denmark3 Copenhagen Center for Health Technology, Center, Technical University of Denmark4 University of Copenhagen
The human gut microbiota plays an important role for human health. The question is whether we can modulate the gut microbiota by changing diet. During a 6-month, randomised, controlled dietary intervention, the effect of consuming a diet following the New Nordic Diet recommendations (NND) as opposed to Average Danish Diet (ADD) on the gut microbiota in humans (n=62) was investigated. Quantitative PCR analysis showed that the microbiota did not change significantly by the intervention. Nevertheless, by stratifying subjects into two enterotypes, distinguished by the Prevotella/Bacteroides ratio (P/B), we were able to detect significant changes in the gut microbiota composition resulting from the interventions. Subjects with a high-P/B experienced more pronounced changes in the gut microbiota composition than subjects with a low-P/B. The study is the first to indicate that enterotypes influence microbiota response to a dietary intervention. The distinguishment of enterotypes by P/B could be a simple approach to assess the effect of diets and other treatments on the gut microbiota.
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8th Danish Conference on Biotechnology and Molecular Biology, 2013