1 Department of Agriculture & Ecology, Plant and Soil Science, Department of Agriculture & Ecology, Faculty of Life Sciences, Københavns Universitet2 Max-Planck Institute for Plant Breeding Research3 RWTH Aachen University4 Department of Agriculture & Ecology, Plant and Soil Science, Department of Agriculture & Ecology, Faculty of Life Sciences, Københavns Universitet5 RWTH Aachen University
The generation of intracellular microbe-associated molecular pattern (MAMP)-triggered Ca ( 2+) transients was recently demonstrated to involve ionotropic Glutamate Receptor (iGluR)-like channels in Arabidopsis and tobacco. Here we elaborate on our previous findings and refine our insights in the putative agonist binding profile and potential mode of desensitization of MAMP-activated plant iGluRs. Based on results from pharmacological inhibition and desensitization experiments, we propose that plant iGluR complexes responsible for the MAMP-triggered Ca ( 2+) signature have a binding profile that combines the specificities of mammalian NMDA-and non-NMDA types of iGluRs, possibly reflecting the evolutionary history of plant and animal iGluRs. We further hypothesize that, analogous to the mammalian NMDA-NR1 receptor, desensitization of plant iGluR-like channels might involve binding of the ubiquitous Ca ( 2+) sensor calmodulin to a cytoplasmic C-terminal domain.
Plant Signalling and Behavior, 2012, Vol 7, Issue 11, p. 1373-1377