Aarestrup, Julie3; Kyrø, Cecilie3; Knudsen, Knud E B6; Weiderpass, Elisabete4; Christensen, Jane3; Kristensen, Mette5; Würtz, Anne M L3; Johnsen, Nina Føns3; Overvad, Kim7; Tjønneland, Anne3; Olsen, Anja3
1 Department of Animal Science - Molecular nutrition and reproduction, Department of Animal Science, Science and Technology, Aarhus University2 Department of Public Health - Department of Epidemiology, Department of Public Health, Health, Aarhus University3 Danish Cancer Society Research Center4 Department of Medical Epidemiology and Biostatistics, Karolinska Institute5 Department of Human Nutrition, University of Copenhagen6 Department of Animal Science - Molecular nutrition and reproduction, Department of Animal Science, Science and Technology, Aarhus University7 Department of Public Health - Department of Epidemiology, Department of Public Health, Health, Aarhus University
The phyto-oestrogen enterolactone has been hypothesised to protect against hormone-dependent cancers, probably through its anti-oestrogenic potential. We investigated whether a higher level of plasma enterolactone was associated with a lower incidence of endometrial cancer in a case-cohort study in the 'Diet, Cancer and Health' cohort. The cohort study included 29 875 women aged 50-64 years enrolled between 1993 and 1997. Information on diet and lifestyle was provided by self-administrated questionnaires and blood was drawn from each participant. Time-resolved fluoroimmunoassay was used for biochemical determination of plasma enterolactone. A total of 173 cases and 149 randomly selected cohort members were included. We estimated incidence rate ratio (IRR) and 95 % CI by a Cox proportional hazards model. A 20 nmol/l higher plasma concentration of enterolactone was associated with a non-significant lower risk of endometrial cancer (IRR 0·93, 95 % CI 0·84, 1·04). When excluding women with low enterolactone concentrations (quartile 1) due to potential recent antibiotic use, the association became slightly stronger, but remained non-significant (IRR 0·90, 95 % CI 0·79, 1·02). Menopausal status, hormone replacement therapy or BMI did not modify the association. In conclusion, we found some support for a possible inverse association between plasma enterolactone concentration and endometrial cancer incidence.
British Journal of Nutrition, 2013, Vol 109, Issue 12, p. 2269-75