1 Preventive and Clinical Nutrition, Department of Nutrition, Exercise and Sports, Faculty of Science, Københavns Universitet2 Kræftens Bekæmpelse, København3 Institut for Husdyrvidenskab - Molekylær ernæring og cellebiologi, Aarhus Universitet, Foulum4 Department of Community Medicine, University of Tromsø, Tromsø & Cancer Registry of Norway, Oslo5 Section of Epidemiology, Department of Public Health, Aarhus University, Aarhus6 Preventive and Clinical Nutrition, Department of Nutrition, Exercise and Sports, Faculty of Science, Københavns Universitet
The phyto-oestrogen enterolactone has been hypothesised to protect against hormone-dependent cancers, probably through its anti-oestrogenic potential. We investigated whether a higher level of plasma enterolactone was associated with a lower incidence of endometrial cancer in a case-cohort study in the 'Diet, Cancer and Health' cohort. The cohort study included 29 875 women aged 50-64 years enrolled between 1993 and 1997. Information on diet and lifestyle was provided by self-administrated questionnaires and blood was drawn from each participant. Time-resolved fluoroimmunoassay was used for biochemical determination of plasma enterolactone. A total of 173 cases and 149 randomly selected cohort members were included. We estimated incidence rate ratio (IRR) and 95 % CI by a Cox proportional hazards model. A 20 nmol/l higher plasma concentration of enterolactone was associated with a non-significant lower risk of endometrial cancer (IRR 0·93, 95 % CI 0·84, 1·04). When excluding women with low enterolactone concentrations (quartile 1) due to potential recent antibiotic use, the association became slightly stronger, but remained non-significant (IRR 0·90, 95 % CI 0·79, 1·02). Menopausal status, hormone replacement therapy or BMI did not modify the association. In conclusion, we found some support for a possible inverse association between plasma enterolactone concentration and endometrial cancer incidence.
British Journal of Nutrition, 2013, Vol 109, Issue 12, p. 2269-2275