Kapoor, Amit2; Simmonds, Peter2; Cullen, John M2; Scheel, Troels K H3; Medina, Jan L2; Giannitti, Federico2; Nishiuchi, Eiko2; Brock, Kenny V2; Burbelo, Peter D2; Rice, Charles M2; Lipkin, W Ian2
1 Department of Immunology and Microbiology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, Københavns Universitet2 unknown3 Department of Immunology and Microbiology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, Københavns Universitet
The recent identification of nonprimate hepaciviruses in dogs and then in horses prompted us to look for pegiviruses (GB virus-like viruses) in these species. Although none were detected in canines, we found widespread natural infection of horses by a novel pegivirus. Unique genomic features and phylogenetic analyses confirmed that the tentatively named equine pegivirus (EPgV) represents a novel species within the Pegivirus genus. We also determined that EPgV causes persistent viremia whereas its clinical significance is undetermined.
Journal of Virology, 2013, Vol 87, Issue 12, p. 7185-90
Amino Acid Sequence; Animals; Base Sequence; Flaviviridae; Flaviviridae Infections; Horse Diseases; Horses; Molecular Sequence Data; Phylogeny; Prevalence; Sequence Analysis, DNA; Species Specificity; United States; Viremia; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't