The recent identification of nonprimate hepaciviruses in dogs and then in horses prompted us to look for pegiviruses (GB virus-like viruses) in these species. Although none were detected in canines, we found widespread natural infection of horses by a novel pegivirus. Unique genomic features and phylogenetic analyses confirmed that the tentatively named equine pegivirus (EPgV) represents a novel species within the Pegivirus genus. We also determined that EPgV causes persistent viremia whereas its clinical significance is undetermined.
Journal of Virology, 2013, Vol 87, Issue 12, p. 7185-90
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Amino Acid Sequence; Animals; Base Sequence; Flaviviridae; Flaviviridae Infections; Horse Diseases; Horses; Molecular Sequence Data; Phylogeny; Prevalence; Sequence Analysis, DNA; Species Specificity; United States; Viremia