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Xenoestrogenic and dioxin-like activity in blood of East Greenland polar bears (Ursus maritimus)

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Authors:
  • Erdmann, Simon Erik ;
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    Department of Public Health - Institute of Environmental and Occupational Medicine, Department of Public Health, Health, Aarhus University
  • Dietz, Rune ;
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    Department of Bioscience - Arctic Research Centre, Roskilde, Department of Bioscience, Science and Technology, Aarhus University
  • Sonne, Christian ;
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    Orcid logo0000-0001-5723-5263
    Department of Bioscience - Arctic Research Centre, Roskilde, Department of Bioscience, Science and Technology, Aarhus University
  • Bechshøft, Thea Ø ;
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    Department of Bioscience - Roskilde, Department of Bioscience, Science and Technology, Aarhus University
  • Vorkamp, Katrin ;
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    Department of Environmental Science - Environmental chemistry & toxicology, Department of Environmental Science, Science and Technology, Aarhus University
  • Letcher, Robert J ;
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    unknown
  • Long, Manhai ;
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    Department of Public Health - Centre for Arctic Health, Department of Public Health, Health, Aarhus University
  • Bonefeld-Jørgensen, Eva C
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    Department of Public Health - Centre for Arctic Health, Department of Public Health, Health, Aarhus University
DOI:
10.1016/j.chemosphere.2013.03.059
Abstract:
The aims of the project were to (i) extract the lipophilic persistent organic pollutants (POPs) from the blood of 99 East Greenland polar bears and assess the combined mixture effect on the estrogen receptor (ER) and the aryl hydrocarbon receptor (AhR) mediated transactivity; (ii) To evaluate whether the receptor transactivities were associated with selected POP markers, and (iii) compare the receptor transactivities in polar bears with earlier studies on Greenlandic Inuit. Lipophilic POPs were extracted using a combination of solid-phase extraction (SPE) and high performance liquid chromatography (HPLC). ER mediated transactivity was determined using the ER luciferase reporter MVLN cell assay. The extracts were tested alone (XER) and together with 17β-estradiol (E2) as a physiological mimic (XERcomp). Dioxins and dioxin-like (DL) compounds were extracted by a combination of SPE and the Supelco Dioxin Prep System®. AhR mediated dioxin-like transactivity was determined using the AhR luciferase reporter Hepa 1.12cR cell assay. Agonistic ER transactivity was elicited by 19% of the samples, and a further increased E2 induced ER response was found for 52%, whereas 17% antagonized the E2 induced ER response. Positive correlations were found in subadult bears between XER and several POP biomarkers. XER and XERcomp correlated positively to each other. A total of 91% of the polar bear blood extracts elicited agonistic AhR transactivity. The AhR-TCDD equivalent (AhR-TEQ) median levels were higher among adult bears compared to subadult bears, but not significantly.
Type:
Journal article
Language:
English
Published in:
Chemosphere, 2013, Vol 92, Issue 5, p. 583-591
Main Research Area:
Medical science
Publication Status:
Published
Review type:
Peer Review
Submission year:
2013
Scientific Level:
Scientific
ID:
241655778

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