The NF-κB transcription factor family regulates several genes encoding pro-inflammatory and anti-inflammatory proteins in adipose tissues and in atherosclerotic plaques. The deletion variant allele of the NFKB1 - 94ins/delATTG promoter polymorphism leads to lower transcript levels of the p50 subunit, and the variant allele has been associated with the risk of several inflammatory diseases as well as coronary heart disease where inflammation is important in the pathogenesis. The objective of this study was to explore the potential interaction between the NFKB1-94ins/delATTG promoter polymorphism and general, abdominal, and gluteofemoral obesity in relation to the risk of incident acute coronary syndrome (ACS) in three large independent cohorts.
P L O S One, 2013, Vol 8, Issue 5, p. 1-8
Acute Coronary Syndrome; Adult; Aged; Base Sequence; Female; Follow-Up Studies; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Mutagenesis, Insertional; NF-kappa B; NF-kappa B p50 Subunit; Obesity; Polymorphism, Genetic; Promoter Regions, Genetic; Prospective Studies; Regression Analysis; Sequence Deletion; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't