Stegger, Jakob Gerhard3; Schmidt, Erik Berg3; Berentzen, Tina Landsvig3; Tjønneland, Anne3; Vogel, Ulla Birgitte3; Rimm, Eric3; Sørensen, Thorkild I A4; Overvad, Kim3; Jensen, Majken Karoline3
1 Section for Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, Københavns Universitet2 Department of Public Health, Department of Public Health, Faculty of Health and Medical Sciences, Københavns Universitet3 unknown4 Section for Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, Københavns Universitet
A Follow Up Study in Three Independent Cohorts
The NF-κB transcription factor family regulates several genes encoding pro-inflammatory and anti-inflammatory proteins in adipose tissues and in atherosclerotic plaques. The deletion variant allele of the NFKB1 - 94ins/delATTG promoter polymorphism leads to lower transcript levels of the p50 subunit, and the variant allele has been associated with the risk of several inflammatory diseases as well as coronary heart disease where inflammation is important in the pathogenesis. The objective of this study was to explore the potential interaction between the NFKB1-94ins/delATTG promoter polymorphism and general, abdominal, and gluteofemoral obesity in relation to the risk of incident acute coronary syndrome (ACS) in three large independent cohorts.
P L O S One, 2013, Vol 8, Issue 5, p. 1-8
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Acute Coronary Syndrome; Adult; Aged; Base Sequence; Female; Follow-Up Studies; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Mutagenesis, Insertional; NF-kappa B; NF-kappa B p50 Subunit; Obesity; Polymorphism, Genetic; Promoter Regions, Genetic; Prospective Studies; Regression Analysis; Sequence Deletion