Male-female differences in upregulation of vasoconstrictor responses in human cerebral arteries

Hilda Ahnstedt; Lei Cao; Diana N Krause; Karin Warfvinge; Hans Säveland; Lars Ola Nilsson; Lars Edvinsson

doi:10.1371/journal.pone.0062698

Male-female differences in upregulation of vasoconstrictor responses in human cerebral arteries

Authors:

Ahnstedt, Hilda ;
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Cao, Lei ;
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Krause, Diana N ;
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Warfvinge, Karin ;
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Säveland, Hans ;
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Nilsson, Lars Ola ;
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Biosystems Division
Edvinsson, Lars
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Department of Clinical Medicine, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet

DOI:

10.1371/journal.pone.0062698

Abstract:

Male-female differences may significantly impact stroke prevention and treatment in men and women, however underlying mechanisms for sexual dimorphism in stroke are not understood. We previously found in males that cerebral ischemia upregulates contractile receptors in cerebral arteries, which is associated with lower blood flow. The present study investigates if cerebral arteries from men and women differ in cerebrovascular receptor upregulation.

Type:

Journal article

Language:

English

Published in:

P L O S One, 2013, Vol 8, Issue 4

Main Research Area:

Medical science

Publication Status:

Published

Review type:

Peer Review

Submission year:

2013

Scientific Level:

Scientific

ID:

241336306

Male-female differences in upregulation of vasoconstrictor responses in human cerebral arteries

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