Jørgensen, Kristian Tore3; Jensen, Morten Søndergaard6; Toft, Gunnar7; Larsen, Ann Dyreborg7; Bonde, Jens Peter4; Hougaard, Karin Sørig5
1 Department of Clinical Medicine - Occupational Medicine, Department of Clinical Medicine, Health, Aarhus University2 Department of Clinical Medicine - Department of Paediatrics, Department of Clinical Medicine, Health, Aarhus University3 Studies Office, Faculty of Science, Faculty of Science, Aarhus University, Aarhus University4 Arbejdsmedicinsk Klinik, NBG, Faculty of Health Sciences, Aarhus University, Aarhus University5 Miljø- og Arbejdsmedicin6 Department of Clinical Medicine - Department of Paediatrics, Department of Clinical Medicine, Health, Aarhus University7 Department of Clinical Medicine - Occupational Medicine, Department of Clinical Medicine, Health, Aarhus University
OBJECTIVES: Pregnant hairdressers may be exposed to a mixture of chemicals in their working environment. The possible relationship between these chemical agents and male reproductive tract malformations has raised concern that the working environment of hairdressers might have adverse effects on fetal development. This study assessed the risk of cryptorchidism and hypospadias among boys of maternal hairdressers. METHODS: National population-based registers were used to determine maternal occupation and identify cases of cryptorchidism and hypospadias. The cohort comprised all children born in Denmark from 1980-2007. Using Cox regression, we estimated hazard ratios (HR) with 95% confidence intervals (95% CI) for hospitalization for cryptorchidism and hypospadias from 1980-2009. RESULTS: Boys of hairdressers were not at increased risk of cryptorchidism (134 cases, HR 0.91; 95% CI 0.77-1.08) or hypospadias (33 cases, HR 1.27; 95% CI 0.90-1.79) compared to children of mothers in other occupations (14 988 and 2556 cases of cryptorchidism and hypospadias, respectively). Additional analyses using children of shop assistants and receptionists as controls and restricted to (i) firstborns, (ii) cryptorchidism cases with corrective surgery, (iii) specific birth years, and (iv) women without social benefit payments in gestational weeks 8-14 produced consistent results of no increased risk. CONCLUSION: Our nationwide cohort study shows that, despite exposure to a complex chemical milieu, hairdressers do not have an increased risk of having boys with cryptorchidism and hypospadias.
Scandinavian Journal of Work, Environment and Health, 2013, p. 302-309