OBJECTIVES: The prevalence of allergic diseases including hay fever has increased in the last decades, especially in Westernised countries. The aim of this study was to analyse whether occupational exposure during pregnancy is associated with development of hay fever in 7-year-old Danish children. METHODS: A total of 42 696 women and their children from the Danish National Birth Cohort were categorised according to maternal occupational exposure. Exposure information was obtained by combining job title in pregnancy with a commonly used asthma Job Exposure Matrix. Information on hay fever in the child was obtained by an internet questionnaire at follow-up at 7 years of age. RESULTS: Adjusted logistic regression analyses showed no significant association between maternal occupational exposure during pregnancy and hay fever among the 7-year-old children. Stratifying for atopic status in the children did not change the results. The prevalence of hay fever was 10.0% in the atopic children compared with 3.6% in the non-atopic children. Maternal atopic disposition increased the risk of hay fever in the offspring, odds ratio (OR) 2.49 [95% confidence interval (CI) 2.26; 2.74]. Rural residence during pregnancy decreased the risk for hay fever [OR 0.74 (95% CI 0.59; 0.92)] as did parity, OR 0.72 (95% CI 0.66; 0.80) and 0.70 (95% CI 0.48; 1.00) for 2nd and 3rd child, respectively, compared with the firstborn child. CONCLUSION: The results suggest that occupational exposure among pregnant women in Denmark is not a risk factor for hay fever among young children. Please cite this paper as: Christensen BH, Thulstrup AM, Hougaard KS, Skadhauge LR, Hansen KS, Schlünssen V. Occupational exposure during pregnancy and the risk of hay fever in 7-year-old children. Clin Respir J 2012; ••: ••-••. DOI:10.1111/j.1752-699X.2012.00300.x.
Clinical Respiratory Journal, 2013, Vol 7, Issue 2, p. 183-188
Journal Article; Research Support, Non-U.S. Gov't; allergy; hay fever; maternal exposure; prenatal exposure delayed effects; prospective cohort study; occupational exposure