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Low plasma arginine:asymmetric dimethyl arginine ratios predict mortality after intracranial aneurysm rupture

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Authors:
  • Staalsø, Jonatan Myrup ;
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    Graduate School of Health and Medical Sciences, Faculty of Health and Medical Sciences, Københavns Universitet
  • Bergström, Anita ;
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    unknown
  • Edsen, Troels ;
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    unknown
  • Weikop, Pia ;
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    Neuropharm and Genetics, Department of Neuroscience, Faculty of Health and Medical Sciences, Københavns Universitet
  • Romner, Bertil ;
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    Section of Neurology, Psychiatry and Sensory Sciences, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet
  • Olsen, Niels Vidiendal
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    Orcid logo0000-0001-7724-3981
    Eyepath Lab, Department of Neuroscience, Faculty of Health and Medical Sciences, Københavns Universitet
DOI:
10.1161/STROKEAHA.111.000605
Abstract:
Asymmetrical dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthases, predicts mortality in cardiovascular disease and has been linked to cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH). In this prospective study, we assessed whether circulating ADMA, arginine:ADMA ratio, and nitrite/nitrate levels were associated with survival and cerebral vasospasm in SAH patients.
Type:
Journal article
Language:
English
Published in:
Stroke, 2013, Vol 44, Issue 5, p. 1273-81
Keywords:
Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Arginine; Biological Markers; Blood Flow Velocity; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Vasospasm, Intracranial; Journal Article; Research Support, Non-U.S. Gov't
Main Research Area:
Medical science
Publication Status:
Published
Review type:
Peer Review
Submission year:
2013
Scientific Level:
Scientific
ID:
240908306

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