The chemotherapy required to treat patients with sarcoma may as a side-effect induce infertility in girls and young women. If these patients have ovarian cortical tissue cryopreserved prior to chemotherapy, they may, if necessary, have the tissue transplanted and restore their fertility. The aim of this study was to evaluate the risk of residual cancer cells in the ovarian cortex intended for transplantation.
European Journal of Cancer (oxford, England : 1990), 2013, Vol 49, Issue 8, p. 1932-1938
Journal Article; Research Support, Non-U.S. Gov't; Adolescent; Adult; Animals; Child; Cryopreservation; Female; Fertility Preservation; Humans; Mice; Mice, Inbred Strains; Mice, Nude; Oncogene Proteins, Fusion; Ovary; Proto-Oncogene Protein c-fli-1; RNA-Binding Protein EWS; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; Sarcoma; Sarcoma, Ewing; Time Factors; Transplantation, Heterologous